Who is eligible?
- First or last author of the publication, must be an ESM member at the time of the proposal and will be the recipient of the prize.
- First or last author can only be awarded one prize a year.
- In cases where there are co-first authors, it is sufficient for one of them to be an ESM member.
- Submitted papers must have appeared within 6 months of the deadline, defined as the date of online publication.

Each quarter, a prize of €500 will go to the first author (to be shared in the case of 2 first authors) and the winner will be asked to present their papers via a webinar during the month following the declaration of the winners. The presentations will be shown live on YouTube and will remain on the ESM website for those who could not watch them live. The 4 winners for each quarter will automatically be entered in the Paper of the Year Hugo David Award.

Proposals and selection process
- The deadline for submitting publications will be 31 March, 30 June, 30 September and 31 December each year and the winner for each quarter will be announced within the month following the deadline. 
- Proposals are to be emailed to the ESM office (office@esmycobacteriology.eu). Please include an abstract along with a PDF copy of your paper.
- The ESM Steering Committee will review the entries.

Survival of hypoxia-induced dormancy is not a common feature of all strains of the Mycobacterium tuberculosis complex

published in Scientific Reports

Barbara Tizzano, Tobias K. Dallenga, Christian Utpatel, Jochen Behrends, Susanne Homolka, ThomasA. Kohl & Stefan Niemann

In this publication, Barbara Tizzano, Tobias Dallenga, Christian Utpatel, and colleagues showed that clinical isolates of not every lineage belonging to the M. tuberculosis complex are able to resuscitate from prolonged periods of oxygen starvation. Previous text book knowledge was that reactivation from dormanxy under hypoxic conditions was a common feature of all strains of the Mycobacterium tuberculosis complex. While all clinical isolates from different sub-lineages of lineage 4 (Euro-American) re-gained ability to proliferate, those belonging to lineage 1 (East African-Indian), lineage 2 (Beijing), and lineage 3 (Delhi/ Central Asian) did not reactivate upon exposure to oxygen in terms of growth, metabolism, and transcription. Transcriptome analysis showed a distinc gene expression program for H37Rb (L4) and Beijing (L2) upon oxygen starvation. These findings could provide deeper understanding in infection dynamics and epidemiology of different lineages of the Mycobacterium tuberculosis complex and may help to develop host-directed therapies and drugs that target the dormant state of mycobacteria.